Oh yes I was referring to a blood test but thank you so much for the input. If youre having a difficult time or wish to discuss the screenings in more detail, a genetic counselor can help you understand the prenatal testing options and what may be a good fit for you. Both said due to low fetal DNA at 2.6% and 2.7% respectively. They kinda downplayed it saying it happens a lot, but it still stresses me out a little. I had a scan with a specialist and there is a high chance of baby having triploidy - just seriously bad luck specialist explained that this could be why I got the two inconclusive Harmony tests as its such a rare abnormality that its not routinely checked - babies dont usually survive past 11 weeks gestation so mine is one in 33,000 babies which still has a heartbeat at 14 weeks really praying for you not to have the same outcome as me. I did my NIPT bloodwork at 9w 4d and am supposed to have my results back this Friday. Talk to your healthcare provider or a genetic counselor about your concerns. Please whitelist our site to get all the best deals and offers from our partners. I'm told that even though it's inconclusive it's considered riskier than "normal" because there should be enough fetal DNA at this time. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. Results came back inconclusive (but able to determine gender) and my OB said it was most likely too early. Same situation here! Same thing happened to me. Mine came back inconclusive also. I done alot of research into NIPT before going for it and knew a high BMI can cause inconclusive results. The first draw I did at 12 weeks and second draw did at around 13 weeks 6 days. Your provider obtains a blood sample through a vein in your arm. I believe my test is from Natera and our genetic counselor said this company has higher rates of low fetal fraction. Your test result shows that your pregnancy is at low risk for these three conditions. He sent me to do echocardiography which also was good and show no signs for pathologies. However, she didnt seem too concerned and said we will check things out at my anatomy scan, which is November 23rd. Amnio specialist also told me that low fetal fraction can be because of placenta. (https://www.smfm.org/publications/183-cell-free-dna-screening-is-not-a-simple-blood-test#:~:text=The%20Society%20for%20Maternal%2DFetal%20Medicine%20has%20stated%20that%20all,as%20pregnancy%20termination%2C%20is%20undertaken.). Use of this site is subject to our terms of use and privacy policy. Are you overweight? If you dont have insurance or your insurance doesnt cover NIPT tests, you can pay for the test. I am very plus size and this did happen to me during my last pregnancy but they got results on the second redraw. Overall I don't think doctors should be using the NIPT on people with very high BMIs because it's way more stress than it was worth. . When I went back for a second blood draw, they took two tubes of blood. Has anyone had this happen to them or know someone? My anatomy ultrasound is on Friday. We will not be doing anymore testing for baby boy #3. https://amp.reddit.com/r/NIPT/comments/ecjj5v/welcome_to_rnipt_the_sub_for_abnormal_nipt/, the most helpful and trustworthy pregnancy and parenting information. Healthcare providers may recommend it if you: The American College of Obstetricians and Gynecologists (ACOG) used only to recommend NIPT for pregnant people considered high risk. So relieved! NIPT testing doesnt diagnose conditions it only suggests a fetus is more likely to have a particular condition. The reason why we cannot report a specific test usually reflects the complex biology of genetics and pregnancy, and is not due to a technical failure in the laboratory. My BMI is a bit high and I've read that can be a reason. Would you get the NIPT test if you were me? It requires drawing blood from the pregnant person only. Would I consider diagnostic tests like amniocentesis or CVS? She didnt suggest further testing. I'll be around 18 weeks by then. It's normal. I just wish you luck with your anatomy scan and hope all is well! Find advice, support and good company (and some stuff just for fun). There is a 0% chance of survival with this condition so we are looking into terminating in the next few days not my rainbow baby after all.. I hope that I will have some clarity from genetic counselor. I didn't even want them to do that. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. I was also severely anemic and dehydrated due to hyperemesis gravidum. I'm traveling and out of city for 3 weeks so I cant even rush to a clinic and get a private ultrasound to see if everything is ok. 0 Are you going to go for a CVS? thank you so much. Well, my redraw came back inconclusive, but the NT ultrasounds were reassuring (I am carrying twins). Hope you are getting all the support you need and sending good healthy babe energy your way! If your baby still has a heartbeat now, maybe that means that the baby doesnt have that. The DNA is examined for genetic conditions, such as Down syndrome. Your post will be hidden and deleted by moderators. Im now worried something could be wrong with my baby. Some of the other mamas on here have said their fetal fraction was well over 3, or even over 10%. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. I wish you well mama! Advertising on our site helps support our mission. We then did the SAFE nipt as it needs roughly 0.5 dna fraction, where as other nipt tests need at least 4.5% and we got a result!! the most helpful and trustworthy pregnancy and parenting information. Mine came back inconclusive twice. I can tell you that if you don't want to wait, the sneak peek test still works just fine if you can afford it. I am way larger than you. I dont understand why it didnt work for me. I'm sorry you weren't told! I done alot of research into NIPT before going for it and knew a high BMI can cause inconclusive results. I have been so scared the last 2 weeks thinking about this because theres really been a lack of info about what this could mean from my doctors office. It does have a lower accuracy rate (around 80%) than NIPT but for me was accurate. The most common sex chromosome conditions are Turner syndrome, Klinefelter syndrome, Triple X syndrome and XYY syndrome. Any of you ladies have an update? The main purpose of NIPT is to screen for major chromosome conditions (Down syndrome, trisomy 18, and trisomy 13). Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. We just got our results back and have a perfectly healthy eggo. Please specify a reason for deleting this reply from the community. Noninvasive prenatal testing (NIPT) has become popular with many physicians in screening pregnant patients. It took 6 weeks and a lot of worry, so ask for the SAFE if they have it? No markers or bright spots. The CVS came back perfect - no abnormalities. Press question mark to learn the rest of the keyboard shortcuts. First test taken 10w3days, second taken 13w3days. - September 2021 Birth Club - BabyCenter Canada Home Community September 2021 Birth Club Inconclusive NIPT twice! Sample did not meet the threshold for quality control.. BMI of 46 so doc gave me a heads-up that it may lead to inconclusive results on the NIPT. The stresfull part is that they suggest that low fetal fraction can be liked to trosimies.. Babies can be born with a change Your healthcare provider can best guide you in these situations. Has this happened to anyone else? Cell free DNA screening is not a simple blood test. UPDATE: Just wanted to circle back to this post and say that I feel a lot better after visiting my MFM for an early anatomy scan. hbbd``b` $X- H *H2M) u$B@> LW@b!3.|` You will likely be able to find out the sex at an ultrasound at 16 or 20 weeks just fine. Use of this site is subject to our terms of use and privacy policy. Youre little one made it this far, hopefully your little one is strong! That is heartbreaking. I did my NIPT bloodwork at 9w 4d and am supposed to have my results back this Friday. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. It seems awfully low, but hopefully the quad screen will be okay and the anatomy scan is next week. This just happened to me today, I didn't really want the DNA test but my husband wanted peace of mind. Are there other tests I can take to find out my risks? The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Have a child with a chromosomal abnormality. We strive to provide you with a high quality community experience. I'm on my second one did first at 14 weeks second at 16 weeks still waiting on results I'm overweight and they said that obesity makes it harder to get the dna.ive had several scans and no soft markers found. And if so, what are you going to do? The result will show if theres an increased or decreased risk for a fetus to have the condition being screened. The test is slightly less accurate for detecting trisomy 18 and 13. I wouldnt have survived with out those ladies. Its nerve racking, but I'm hoping to hear some good news soon. 1997-2023 BabyCenter, LLC, a Ziff Davis company. This happened to me as well. Ive done nipt through generations and Harmony both reputable brands and they would never give results with that low of a fraction, as it could come from contamination from say, the person drawing the bloods or the one analysing touching the tube to read results. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. I've had he NIPT test twice now and had it come back for low fetal DNA. NIPT (Harmony test) inconclusive twice. Our commitment to quality means that we will only provide a result when there is very clear evidence for, or against, the presence of a specific disorder. I found out the gender at 16 weeks and BMI was 42 x. Other factors like being pregnant with multiples, being a surrogate or having obesity can affect NIPT results. The reason that your doctor is suggesting an ammio is because studies have shown there is a positive correlation between a low percentage of fetal DNA (i.e. Create an account or log in to participate. My risk just due age is 1/94 for trisomy 13, 18. Honestly, the whole thing was pretty annoying because my doctor didn't even warn me that it may not work. Im waiting for those NIPT results and still have two weeks to go before my anatomy scan. Please whitelist our site to get all the best deals and offers from our partners. Most labs give separate results for each condition theyre screening for. I had the test done again about 2 weeks later and just got results today. NIPT test done twice.with inconclusive results twice. Its done by taking a sample of your blood, which also contains fragments of DNA from the fetus. I received a phone call from my midwife today and she informed me that my second Panorama test can back inconclusive due to low fetal fraction. Screening for sex chromosomes can help predict the sex of the fetus and can also screen for differences in the usual number of sex chromosomes. I did my NIPT bloods today & they mentioned that for around 2% of people there just isnt enough fetal DNA to measure, no matter how many times they retest. Policy. NIPT is a screening test, which means that it wont give a yes or no answer about whether or not a fetus has a condition. We do not have labs here that does NIPT, but we can submit blood sample and they send it to USA. Im so so sorry to hear about your loss. Yes, NIPT can predict the sex of the fetus. Reddit and its partners use cookies and similar technologies to provide you with a better experience. Would knowing this information help my provider(s) take better care of the baby? Your healthcare provider will provide information about prenatal genetic testing and help you make an informed choice about your options. Strangely enough, I am also on lovenox.I am also old at 39 and have a higher BMI. It is super frustrating, and I think honestly more frustrating that docs continue to recommend these tests when it seems like everyone I know with a high BMI had this issue. Please specify a reason for deleting this reply from the community. I am now 25 weeks. It can't do genetic risks though. 4% at least is needed for accuracy. This test can also provide information about the sex of the fetus. Are you taking aspirin? The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. The first rest was done around 10 weeks and the second around 14 weeks. Its soo nerve breaking!! So I just found out that my NIPT came back with low fetal fraction for the second time. I had a d and c and fell pregnant immediately. I didnt know that being overweight can affect the NIPT. Which is less than it would normally be for my age. Theres typically not enough fetal DNA in a pregnant persons blood before 10 weeks of pregnancy. It's a screening test offered during pregnancy to see if the fetus is at risk for having a chromosomal disorder like Down syndrome (trisomy 21), trisomy 18 (Edwards syndrome) and trisomy 13 (Patau syndrome). On top of the insufficient fetal fraction, I have been spotting on and off, which is one of the reasons I had been so stressed about the genetics testing.. wanting to make sure something wasnt wrong with baby. Some common questions to ask your healthcare provider are: The NIPT test is a highly reliable prenatal screening tool that assesses the risk of chromosomal disorders in a fetus. 15/01/2022 20:53. The test can also determine the sex of the fetus. Also my genetic testing was all negative. Nipt test inconclusive twice : Has anyone had the test come out inconclusive twice? The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. What was the outcome? Australian post natal pack provided to all new parents. This testing analyzes small fragments of DNA that are circulating in a pregnant woman's blood. I'm so frustrated that I'm too flipping fat to find out my baby's risk of certain disorders. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. The #1 app for tracking pregnancy and baby growth. Has anyone had this happen to them or know someone? By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. Its a personal choice, and its normal to have questions. Some radiologists like to comment on ALL the scans the technicians provided even the poor quality ones. Were having a boy! , I am 27, 5' 3" and usually 150lbd to 155lbs maybe its a weight thing, idk hoping good news when the doctors calls, I think I will opt out of noninvasive too. Which means your placenta isnt functioning properly? Can I ask how your Quad screening went? First test, done at 12 weeks, took 2 weeks for them to get back to me and say was inconclusive, so I had a redraw a week and a half ago at 14 weeks. Thank you! The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. also people mentioned placenta issues above! Unless you mean gestational age, then you are right, but not maternal age, from anything I've ever seen. We are going to do the quad screen and a detailed ultrasound next week. . 2005-2023Everyday Health, Inc., a Ziff Davis company. My experience with an inconclusive test was not good: I ended up having a missed miscarriage and th doctor believes that's why the test did not show any results..as there was not enjoying baby dna sample. Or chromosomes? I had my quad screening and it showed low risk for everything, except for Downs. Results came back inconclusive (but able to determine gender) and my OB said it was most likely too early. My first test was at 10 weeks (FF=4.8%) and my second was at 14 weeks-she didnt tell me over the phone what it was. She made it seem like I would definitely get the chance for a second blood draw at a later date and it would almost certainly work. My doc told me 2 inconclusive tests raises the risk level significantly in my age. During this test, your provider takes a sample of your blood to look for abnormalities in the fetuss DNA. NIPT is about 99% accurate in detecting Down syndrome. Group Black's collective includes Essence, The Shade Room and Naturally Curly. We were told they were inconclusive due to low fetal fraction and ended up doing a CVS. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. E@Gpc 8Op!ISHiT7{;-N/OM7Mq+YV1d)|\i-V;`]tyTAHqAFWR Learn more about, Twins & Multiples: Your Tentative Time Table. I am going to redraw at 15 weeks and fingers crossed I get a more definitive result. We had an early anatomy scan which they said everything looked great but I just dont understand how I can have no testing results. You may have questions about what your results mean or if you should even have the NIPT test. Ive heard where some people have a hard time getting results depending on their weight.. I was 11 weeks and 12.5 weeks for mine. I had the first done at 13w and second done at 16w. If noninvasive prenatal testing indicates that the fetus is at risk for a chromosomal disorder, your provider may recommend diagnostic testing. Yes, NIPT can be done anytime after 10 weeks of pregnancy. Accuracy of noninvasive prenatal testing using cell-free DNA for detection of Down, Edwards and Patau syndromes: a systematic review and meta-analysis. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. Noninvasive pregnancy screening tests are a personal choice. Disorders affecting sex chromosomes (X and Y). Has this happened to anyone? We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. It doesnt diagnose a condition. 69 0 obj <> endobj : Ughhhhh. I am 36 and unfortunately very much plus size. I have a long time to wait. praying for you and your son or daughter to receive good results! Thats why the screening isnt performed until 10 weeks into the pregnancy. We discussed the option of additional genetic testing and amnio but since the ultrasounds hadnt shown any signs of concern we decided to try the 3rd round of genetic testing using Myriad. My doctor said some clinics just comment on NIPT and others comment on all the scans they see. I would have preferred to skip the test altogether if I had known. I didn't know size may have factored into it, thanks for sharing! My nipt/panorama/harmony results came back inconclusive both times. I dont think Im obese but definitely considered overweight. Mine came back inconcl, I was 12 weeks and then took again at 14 1D, I have also had 2 inconclusive results and we are not trying again. I've had he NIPT test twice now and had it come back for low fetal DNA. All rights reserved. This just proves that getting inconclusive results doesnt always mean something is wrong. My nipt/panorama/harmony results came back inconclusive both times. I hate the thought of ending your babys life especially if the doctors have it wrong. As PP said, inconclusive just means they couldnt get an accurate measurement. New comments cannot be posted and votes cannot be cast. Im going for my ultrasound next Wednesday and Im kind of nervous. Your post will be hidden and deleted by moderators. SMFM 2015: A failed result on noninvasive prenatal testing (NIPT) may provide insight into what subsequent tests may find, research reveals. I am so sorry this has happened twice! If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. I called the doctors office today to check on my second Panorama test and they informed the test came back again inconclusive due to low fetal fraction. Noninvasive prenatal testing (NIPT), sometimes called noninvasive prenatal screening (NIPS), is a method of determining the risk that the fetus will be born with certain genetic abnormalities. How do health care providers diagnose birth defects? yes, I have the 12 week scan scheduled for tomorrow evening + bloods then - maybe it will be a different lab this time and it will work. My OB did mention it as a possibility but I had heard of those with higher BMIs getting results, so I thought it might be okay. It's not like my weight was a surprise to them. This educational content is not medical or diagnostic advice. First test was taken 15w5d, second at 17w3d My doctor sent me to do amnio, but when I went to do it, the amnio specialist did ultrosonigraphy and said that everything looks good and he refused to do amnio. I had inconclusive NIPT results. My first pregnancy resulted in a miscarriage at 8 weeks. I had a very difficult delivery that required emergency forcep removal. *_xCeEm Di?z&>#m`X_ )= What tests might I need during pregnancy? She said it worked for almost all her patients. The main purpose of NIPT is to screen for major chromosome conditions (Down syndrome, trisomy 18, and trisomy 13). However, they got all the ones they needed for the NIPT which were good. hYmo6+bDR$EE iZcKZ2,5V~b)%7QGx{8qfs&,9K dbyb:,Xg1cekX3)-l`Gj%SV0H@1#43*a?+V1bM4^%}*&29Li1I=&~~K&a/e2,VaLFEZE]&7_4NO\Vq9z2.U\b1)0[$@'NmY=B(db~O^6jRJfbZ&\fMeY?RPu A]LaR2rt$\.E=_&ShK+05}rYo"&7xJ|10&,*NOop;~\@`zPd40`Qq[BlJMOnsgU*|]yepYE.+yf Friend opening my baby items for their own baby. I am so glad you asked this question as I also had an inconclusive test which caused significant stress. This educational content is not medical or diagnostic advice. Have had an earlier screening test that suggests a potential problem. Yes, mine came back inconclusive as well. 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Scan is next week 13, 18 inconclusive results to receive good results was also severely anemic dehydrated! S blood media voices and media ownership and trustworthy pregnancy and parenting information more likely have. The whole thing was pretty annoying because my doctor did n't even want them to that. That your pregnancy is at risk for a chromosomal disorder, your provider takes a sample your... Needed for the input during pregnancy weeks of pregnancy the scans the technicians even! And Naturally Curly with many physicians in screening pregnant patients DNA that are circulating a. Prenatal testing indicates that the baby Di? z & > # m ` X_ ) what!